are allergic to xylometazoline or any ingredients of this medicine
are currently taking monoamine oxidase (MAO) inhibitors (e.g., phenelzine, tranylcypromine)
are sensitive (i.e., experience trouble sleeping, dizziness, lightheadedness, weakness, tremor, or abnormal heart rhythms) to other related medications (e.g., epinephrine, phenylephrine, pseudoephedrine)
have narrow-angle glaucoma
have rhinitis sicca (a chronic type of rhinitis with very little or no discharge in nose)